Ets-1 Oncoprotein Novocastra
The proto-oncogene c-Ets-1 is a transcription factor known to regulate expression of a number of genes involved in extracellular matrix remodelling. The processes of tumor invasion and metastasis are thought to depend on the increased proteolytic activity of the invading tumor cells that may involve matrix metalloproteinases, cathepsins B and D and plasminogen activator in the metastatic cascade. Ets-1 interacts with the urokinase-type plasminogen activator gene enhancer and with the promoters of stromelysin-1 (MMP3) and collagenase-1 (MMP1) gene which may implicate it in this process. The Ets-1 proto-oncogene is also preferentially expressed in lymphoid cells, where it is essential for the maintenance of the normal pool of resting T and B cells. Ets-1 expression level and distribution are differentially controlled in resting, activated and apoptotic lymphocytes.