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Dystrophin Antibodies Muscle Disease Antibodies

Dystrophin Antibodies

Human skeletal muscle: immunohistochemical staining for dystrophin using NCL-DYSA. Note membrane staining of normal muscle fibers (A) and reduced and variable staining of revertant muscle fibers in an individual with Duchenne muscular dystrophy (B).
Human skeletal muscle: immunohistochemical staining for dystrophin using NCL-DYSA. Note membrane staining of normal muscle fibers (A) and reduced and variable staining of revertant muscle fibers in an individual with Duchenne muscular dystrophy (B).

Antigen Background

Duchenne Muscular dystrophy (DMD) is the most common of the muscular dystrophies resulting in progressive muscular wasting and death. Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Abnormalities in protein expression occur in patients with DMD/BMD and dystrophin analysis may be used to distinguish these conditions from other neuromuscular diseases. Severe Duchenne muscular dystrophy is associated with a marked dystrophin deficiency, whereas patients with the milder form of Becker muscular dystrophy show less pronounced abnormalities of protein expression. The immunolabeling patterns for NCL-DYS1, NCL-DYS2 and NCL-DYS3 are similar; however, the use of all three antibodies is recommended to avoid the possibility of occasional false negative results.


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CLONE: 13H6

Material with code "Dystrophin Abs" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
DYSA 1ml NCL-DYSA Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS

CLONE: 34C5

Material with code "Dystrophin Abs" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
DYSB 1ml NCL-DYSB Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS

CLONE: DY10/12B2

Material with code "Dystrophin Abs" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
DYS3-CE-S 1ml NCL-DYS3 Lyophilised Concentrated Monoclonal Antibody F Info MSDS
DYS3-CE 2.5ml NCL-DYS3 Lyophilised Concentrated Monoclonal Antibody F Info MSDS
DYS3-S 1ml NCL-DYS3 Lyophilised Concentrated Monoclonal Antibody E, F, W Info MSDS
DYS3 2.5ml NCL-DYS3 Lyophilised Concentrated Monoclonal Antibody E, F, W Info MSDS

CLONE: DY4/6D3

Material with code "Dystrophin Abs" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
DYS1-CE-S 1ml NCL-DYS1 Lyophilised Concentrated Monoclonal Antibody F Info MSDS
DYS1-CE 2.5ml NCL-DYS1 Lyophilised Concentrated Monoclonal Antibody F Info MSDS

CLONE: DY8/6C5

Material with code "Dystrophin Abs" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
DYS2-S 1ml NCL-DYS2 Lyophilised Concentrated Monoclonal Antibody E, F, W Info MSDS
DYS2 2.5ml NCL-DYS2 Lyophilised Concentrated Monoclonal Antibody E, F, W Info MSDS
DYS2-CE-S 1ml NCL-DYS2 Lyophilised Concentrated Monoclonal Antibody F Info MSDS
DYS2-CE 2.5ml NCL-DYS2 Lyophilised Concentrated Monoclonal Antibody F Info MSDS