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Choline Acetyltransferase Primary Antibodies

Choline Acetyltransferase Novocastra

Human brain, basal ganglia: immunohistochemical staining for choline acetyltransferase using NCL-ChAT. Note cytoplasmic staining of neurons of the nucleus basalis of Meynert. Paraffin section.
Human brain, basal ganglia: immunohistochemical staining for choline acetyltransferase using NCL-ChAT. Note cytoplasmic staining of neurons of the nucleus basalis of Meynert. Paraffin section.

Antigen Background

Choline acetyltransferase (ChAT) is a 68 kD enzyme which catalyzes the synthesis of acetylcholine (ACh) from choline and acetyl coenzyme A. The human ChAT gene encodes two proteins, the 68 kD ChAT enzyme and a 27kD protein immunologically related and coexpressed with ChAT in cholinergic neurons of the central nervous system. The smaller protein may play a role in the regulation of ACh synthesis. ChAT is expressed in cholinergic neurons, the majority of the neurons in the nucleus basalis of Meynert, large neurons in the striatum (putamen and caudate nuclei), the majority of neurons in the pedunculopontine, hypoglossal, dorsal nucleus of vagus and subgroups of neurons in Roller's and the medial olivary accessory nuclei. Prominent staining is observed in ribonucleoprotein, distributed at the periphery of large neurons of the nucleus basalis of Meynert, the motor neurons in the hypoglossal and ambiguus nuclei.

Product Specific Information

NCL-ChAT does not label axons in the insular cortex of the internal capsule non-cholinergic structures, endothelial cells or microglia.


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CLONE: 38B12

Material with code "CHAT" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
CHAT 1ml NCL-ChAT Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
CHAT-U 1ml NCL-ChAT US IVD Lyophilised Concentrated Monoclonal Antibody P(HIER) MSDS