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CDX2 Primary Antibodies

CDX2 Novocastra

Human colonic adenocarcinoma: immunohistochemical staining  for CDX2 homeobox protein using Bond Ready to Use CDX2. Note nuclear and cytoplasmic staining of malignant epithelial-derived cells. Paraffin section.
Human colonic adenocarcinoma: immunohistochemical staining for CDX2 homeobox protein using Bond Ready to Use CDX2. Note nuclear and cytoplasmic staining of malignant epithelial-derived cells. Paraffin section.

Antigen Background

CDX2 is a caudal-type homeobox, intestine-specific transcription factor expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. CDX2, as well as CDX1, is of particular interest as the intestine is the only organ that contains detectable levels of either gene product.

This pattern of restricted expression is unusual for homeobox genes. Phosphorylation of the CDX2 activation domain can modulate its function and different spatial expression patterns in the intestinal epithelium. CDX2 is primarily expressed on the surface of the villus and in the crypts. In contrast to CDX1, intense CDX2 expression is reported to occur in all but the distal portions of the developing intestine.

The loss of CDX2 has been reported to contribute towards the progression of some sporadic colorectal cancers. It has been reported that CDX2 may also be associated with carcinogenesis of the stomach as expression of CDX2 mRNA progressively decreases with the transition from well differentiated to poorly differentiated gastric cancer cell lines.


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CLONE: AMT28

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Code Name Configuration Use Datasheet MSDS Qty
PA0535 7ml CDX2 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
CDX2-L-U 1ml NCL-L-CDX2 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
CDX2 1ml NCL-CDX2 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info
CDX2-U 1ml NCL-CDX2 US IVD Lyophilised Concentrated Monoclonal Antibody P(HIER) MSDS
CDX2-S 0.1ml NCL-CDX2 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS

CLONE: EP25

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Code Name Configuration Use Datasheet MSDS Qty
PA0375 7ml CDX2 (EP25) Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS