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CD141 (Thrombomodulin) Primary Antibodies

CD141 (Thrombomodulin) Novocastra

Antigen Background

Thrombomodulin is a transmembrane glycoprotein of 75 kD which can accelerate the activation of protein C. Activated protein C functions as an anticoagulant by combining with protein S to inactivate factors Va and VIIIa of the blood coagulation pathway and by binding thrombin. Several factorsregulate thrombomodulin expression. Downregulation of thrombomodulin may be induced by the cytokine interleukin-1, tumor necrosis factor and endotoxin. Agents which increase cyclic AMP such as forskolin may upregulate thrombomodulin activity in endothelial cells. Thrombomodulin has been identified within a number of normal tissues. These include the lining cells of arteries, veins, capillaries and the lymphatics as well as mesothelial cells, meningeal lining cells, synovial cells, syncytiotrophoblasts,  megakaryocytes and platelets.

 

 


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CLONE: 15C8

Material with code "CD141 (Thrombo)" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
CD141-L-U 1ml NCL-L-CD141 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
CD141 1ml NCL-CD141 Lyophilised Concentrated Monoclonal Antibody F, P(HIER) Info MSDS
CD141-U 1ml NCL-CD141 US IVD Lyophilised Concentrated Monoclonal Antibody F, P(HIER) MSDS
CD141-S 0.1ml NCL-CD141 Lyophilised Concentrated Monoclonal Antibody F, P(HIER) Info MSDS