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Calponin (Basic) Primary Antibodies

Calponin (Basic) Novocastra

Antigen Background

Basic calponin (calponin-h1) is a 34 kD protein which exhibits a high degree of homology to acidic and neutral calponins at its N-terminal region. It is an actin, tropomyosin and calmodulin binding protein thought to be involved in the regulation of smooth muscle contraction. The expression of basic calponin is reported to be restricted to smooth muscle cells and is a marker of the differentiated contractile phenotype of developing smooth muscle. Vascular smooth muscle cells convert to a synthetic dedifferentiated phenotype when this protein is lost and this is a key stage in both atherosclerosis and restenosis of coronary arteries after balloon angioplasty. It is thought that basic calponin exerts its effect via the cortical actin cytoskeleton, and therefore influences proliferation, the transformed phenotype and the metastatic potential of tumor cells. Basic calponin mRNA is expressed in smooth muscle of prostate, bowel and aorta whereas neutral and acidic calponin mRNAs are expressed in non-smooth muscle tissues such as heart, placenta, lung, kidney, pancreas, spleen, testis and ovary as well as in smooth muscle-containing tissues.


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CLONE: 26A11

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Code Name Configuration Use Datasheet MSDS Qty
PA0416 7ml Calponin B Bond RTU Primar Bond ready to use reagent P(HIER) Info MSDS
CALPONIN-B-A 1ml NCL-CALPONIN-B ASR Lyophilised Concentrated Monoclonal Antibody Info MSDS
CALPONIN-B-S 0.1ml NCL-CALPONIN-B Lyophilised Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS