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Calpain Antibodies Muscle Disease Antibodies

Calpain Antibodies

Western blot: analysis of human skeletal muscle showing detection of calpain proteins. Lane A, calpain 3 bands at 94 and 30 kD detected with NCL-CALP-2C4. Lane B, calpain 3 bands at 94 and approximately 60 kD detected with NCL-CALP-12A2.
Western blot: analysis of human skeletal muscle showing detection of calpain proteins. Lane A, calpain 3 bands at 94 and 30 kD detected with NCL-CALP-2C4. Lane B, calpain 3 bands at 94 and approximately 60 kD detected with NCL-CALP-12A2.

Antigen Background

The gene responsible for LGMD2A has been identified as the chromosome 15q15-encoded muscle-specific calcium-activated neutral protease, calpain 3. Calpain 3 enzyme is only stable in human muscle when homogenized in treatment buffer immediately after harvest (Anderson LVB et al. Am. J. of Pathol. 153(4), 1169-1179 (1998)), and in homogenates containing SDS and is therefore well suited for analysis by Western blot. NCL-CALP-2C4 reacts with the full-size calpain 3 (94kD) and an additional fragment (30kD) in human skeletal muscle. NCL-CALP-12A2 reacts with full-size protein plus apparent degradation products at approximately 60kD.


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CLONE: CALP3C/11B3

Material with code "Calpain" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
CALP-11B3 2.5ml NCL-CALP-11B3 Lyophilised Concentrated Monoclonal Antibody W Info MSDS
CALP-11B3-S 1ml NCL-CALP-11B3 Lyophilised Concentrated Monoclonal Antibody W Info MSDS

CLONE: CALP3C/12A2

Material with code "Calpain" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
CALP-12A2-S 1ml NCL-CALP-12A2 Lyophilised Concentrated Monoclonal Antibody W Info MSDS
CALP-12A2 2.5ml NCL-CALP-12A2 Lyophilised Concentrated Monoclonal Antibody W Info MSDS

CLONE: CALP3D/2C4

Material with code "Calpain" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
CALP-2C4 2.5ml NCL-CALP-2C4 Lyophilised Concentrated Monoclonal Antibody W Info MSDS
CALP-2C4-U 2.5ml NCL-CALP-2C4 US IVD Lyophilised Concentrated Monoclonal Antibody W MSDS
CALP-2C4-S 1ml NCL-CALP-2C4 Lyophilised Concentrated Monoclonal Antibody W Info MSDS