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bcl-2 Oncoprotein Primary Antibodies

bcl-2 Oncoprotein

Human follicular lymphoma: immunohistochemical staining for Bcl-2 using PA0117. Note moderate cytoplasmic staining reaction of neoplastic cells, while normal peripheral lymphocytes show a strong staining reaction. Paraffin section.
Human follicular lymphoma: immunohistochemical staining for Bcl-2 using PA0117. Note moderate cytoplasmic staining reaction of neoplastic cells, while normal peripheral lymphocytes show a strong staining reaction. Paraffin section.

Antigen Background

Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.

In 90% of follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.


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CLONE: 3.1

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Code Name Configuration Use Datasheet MSDS Qty
BCL-2-486-S 0.1ml NCL-BCL-2-486 Lyophilised Concentrated Monoclonal Antibody P(HIER), W Info MSDS
BCL-2-486 1ml NCL-BCL-2-486 Lyophilised Concentrated Monoclonal Antibody P(HIER), W Info
BCL-2-486-U 1ml NCL-Bcl-2-486 US IVD Lyophilised Concentrated Monoclonal Antibody P(HIER), W MSDS

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Code Name Datasheet Qty
C-ERBB-2-316-CE- 0.1ml NCL-c-erbB-2-316-CE-S Info

CLONE: BCL-2/100/D5

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Code Name Configuration Use Datasheet MSDS Qty
PA0117 7ml Bcl-2 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
BCL-2-L 1ml NCL-L-bcl-2 Liquid Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS
BCL-2-L-CE 1ml NCL-L-bcl-2 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
BCL-2-L-CE 1ml NCL-L-bcl-2 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
BCL-2-L 1ml NCL-L-bcl-2 Liquid Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS
BCL-2 1ml NCL-bcl-2 Lyophilised Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS
BCL-2-CE-S 0.1ml NCL-bcl-2 Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
BCL-2-S 0.1ml NCL-bcl-2 Lyophilised Concentrated Monoclonal Antibody F, P(HIER), W Info MSDS
BCL-2-O ORG-8714 - 7ml BCL-2-O Origin P Info MSDS
BCL-2-R-7-CE 7ml RTU-bcl-2 Ready to Use Monoclonal Antibody P(HIER) Info MSDS
BCL-2-R-7 7ml RTU-bcl-2 Ready to Use Monoclonal Antibody F, P(HIER) Info MSDS