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ALK Primary Antibodies

ALK

Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin section.
Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin section.

Antigen Background

Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and the epithelial membrane antigen (EMA).These tumor cells tend to occur in younger individuals and may be associated with cutaneous and extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23;q35).This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80.Large cell lymphomas account for approximately 25 percent of all non-Hodgkin's lymphomas in children and young adults, of which one third carries the NPM-ALK gene translocation.


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Code Name Configuration Use Datasheet MSDS Qty
PA0306 7ml ALK Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
ALK-L-H 0.5ml NCL-L-ALK Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
ALK-L-S 0.1ml NCL-L-ALK Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
ALK-L-CE-H 0.5ml NCL-L-ALK Liquid Concentrated Monoclonal Antibody P(HIER) Info
ALK-L-CE-S 0.1ml NCL-L-ALK Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
ALK-S 0.1ml NCL-ALK Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
ALK-CE 1ml NCL-ALK Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
ALK 1ml NCL-ALK Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS
ALK-CE-S 0.1ml NCL-ALK Lyophilised Concentrated Monoclonal Antibody P(HIER) Info MSDS