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Merosin Laminin Alpha 2 Chain

Human skeletal muscle: immunohistochemical staining for merosin using NCL-MEROSIN.  Note membrane staining of normal muscle fibers (A) and absence of staining of muscle fibers in an individual with chromosome 6-linked congenital muscular dystrophy (B). Frozen sections. Photographs supplied courtesy of Dr Louise V B Anderson.
Human skeletal muscle: immunohistochemical staining for merosin using NCL-MEROSIN. Note membrane staining of normal muscle fibers (A) and absence of staining of muscle fibers in an individual with chromosome 6-linked congenital muscular dystrophy (B). Frozen sections. Photographs supplied courtesy of Dr Louise V B Anderson.

Antigen Background

The muscle-specific form of laminin, merosin, is composed of three chains: alpha 2, beta 1 and gamma 1.

Mutations in the chromosome 6 encoded gene for the laminin alpha 2 chain of merosin are responsible for a form of congenital muscular dystrophy (CMD). Merosin-negative CMD is characterized by a severe clinical phenotype and is associated with white matter changes on brain imaging. 


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CLONE: MER3/22B2

Material with code "Merosin" is discontinued , possible alternatives:

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Code Name Configuration Use Datasheet MSDS Qty
MEROSIN-CE 1ml NCL-MEROSIN Lyophilised Concentrated Monoclonal Antibody F Info MSDS
MEROSIN-CE-S 0.1ml NCL-MEROSIN Lyophilised Concentrated Monoclonal Antibody F Info MSDS
MEROSIN 1ml NCL-MEROSIN Lyophilised Concentrated Monoclonal Antibody F Info MSDS