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Mismatch Repair Protein (MLH1) Novocastra HD

Mismatch Repair Protein (MLH1) Novocastra

Human squamous cell carcinoma: immunohistochemical staining for mismatch repair protein,  mlh1  using NCL-L-MLH1.Note nuclear staining staining in a high proportion of malignant cells. Paraffin section.
Human squamous cell carcinoma: immunohistochemical staining for mismatch repair protein, mlh1 using NCL-L-MLH1.Note nuclear staining staining in a high proportion of malignant cells. Paraffin section.

Antigen Background

MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. During DNA replication, strand misalignment can occur resulting in alterations to microsatellite repeats, often referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been linked to human carcinogenesis. Mutations in the MLH1 gene have been reported to be found in some forms of colon cancer, a subset of sporadic carcinomas and breast cancer. Loss of expression of MLH1 has also been reported in acute lymphoblastic leukemia, endometrial carcinoma, gastric carcinoma and ovarian carcinoma.


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Code Name Configuration Use Datasheet MSDS Qty
PA0610 7ml MLH1 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
MLH1-L 1ml NCL-L-MLH1 Liquid Concentrated Monoclonal Antibody P(HIER), W Info MSDS
MLH1-L-CE-S 0.1ml NCL-L-MLH1 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
MLH1-L-CE 1ml NCL-L-MLH1 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
MLH1-L-S 0.1ml NCL-L-MLH1 Liquid Concentrated Monoclonal Antibody P(HIER), W Info MSDS