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P120 Catenin Bond Reagents

P120 Catenin

Human breast carcinoma: immunohistochemical staining  for p120 Catenin antigen using Bond Ready to Use p120 Catenin. Note membrane and cytoplasmic staining of malignant cells. Paraffin section.
Human breast carcinoma: immunohistochemical staining for p120 Catenin antigen using Bond Ready to Use p120 Catenin. Note membrane and cytoplasmic staining of malignant cells. Paraffin section.

Antigen Background

P120 catenin is a regulator of cell-cell adhesion, achieved through interaction with classical and Type II cadherins. Evidence also exists for a role in the regulation of cadherin availability on the cell surface. P120 catenin also regulates actin dynamics, placing it as a potential master regulator of the cell motility/cell adhesion phenotypes.

Recent studies have suggested a tumour-suppression role for p120, with loss of p120 expression implicated in the development of a tumour microenvironment and induction of metastatic progression. The expression of p120 Catenin has been highlighted in early lobular breast neoplasias.


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CLONE: EP66

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Code Name Configuration Use Datasheet MSDS Qty
PA0379 7ml p120 Catenin (EP66) Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS