CD103, also known as alpha E integrin & human mucosal lymphocyte antigen 1, is an integrin protein with expression on intraepithelial T cells & some peripheral regulatory T cells. CD103 is expressed at high levels on tumour-infiltrating FOXP3-positive regulatory T cells in cancer and CD103-positive T cells are strongly associated with patient survival in high-grade serous ovarian cancer.
CD103 expression has been suggested as a definitive marker of intraepithelial, tumour-specific infiltrating lymphocytes. In addition, CD103-positive cells have also been identified in a small proportion of breast cancers.
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|PA0374||7ml CD103 (EP206) Bond RTU Primary|