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Aperio Colocalization Algorithm Analyze

Aperio Colocalization Algorithm – Identify Multiple Biomarker Interactions

Aperio Colocalization Algorithm

Detecting and measuring the colocalization of multiple proteins is an important part of larger scientific studies, which seek to determine a correlation between the occurrence of these proteins and the outcome of a specific disease treatment. The Aperio Colocalization Algorithm determines where specific proteins are present in IHC stained tissue, and to what extent the proteins are “colocalized” – that is, whether they occur separately or in combination with each other.

 

For Research Use Only. Not for use in diagnostic procedures. For specific product indications and more information click here.

Aperio CS2 and Aperio AT Turbo are registered products under the ScanScope® name.

Copyright © 2016 Leica Biosystems Imaging, Inc. All Rights Reserved. LEICA and the Leica logo are registered trademarks of Leica Microsystems IR GmbH. Aperio is a registered trademark of Leica Biosystems Imaging, Inc. in the and other countries.


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Measure staining accurately

The Aperio Colocalization Algorithm calculates the contribution of each chromogen at every pixel location. It classifies each pixel as representing a single stain or a combination of stains, providing you with precise information on the distribution of biomarkers in the tissue.

Analysis that fits your research

Double-label IHC is frequently used to identify cellular and subcellular colocalization of independent antigens, and is a special case of the more general colocalization analysis. The Aperio Colocalization Algorithm includes a double-label IHC analysis mode to meet specialized research needs.

Precise color calibration

Up to 3 stain color vectors can be easily calibrated, so that the algorithm is attuned exactly to your stains. Train the algorithm to recognize your stains, and set thresholds to define the range of color you want to include.

Visual and data-driven results

The Aperio Colocalization Algorithm returns comprehensive outputs, including information on all combinations of colors identified, which can be easily exported or saved. Mark-up annotations on the analyzed region let you confirm results visually with ease.